Den anbefalte daglige dosen av paracetamol bør ikke overskride three–4 gram for en voksen fordelt på et døgn. Ta hensyn til dette ved bruk av andre smertestillende som inneholder paracetamol. – Det er usikkert hvor god effekt langvarig behandling med opioider har på smertelindring. Samtidig vet vi at langvarig opioidbruk kan gi økt risi
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